Brahm H. SEGAL,Scott ABRAMS,Kunle ODUNSI,Melissa GRIMM,Nazmul H. KHAN,Nonna KOLOMEYEVSKAYA,Kelly SINGEL
申请号：
US14774763
公开号：
US20160030558A1
申请日:
2014.03.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided is a method for enhancing the efficacy of cancer vaccines, such as tumor vaccines. The method involves administering to an individual who is in need of therapy for a tumor an anti-cancer agent and an agent that causes depletion of myeloid cells and/or inhibits recruitment of myeloid cells to the tumor. The effect of the anti-cancer agent on the tumor is greater relative to the effect of the anti-cancer agent in the absence of the anti-myeloid cell agent. Also provided is a method for identifying candidates for the therapy. This approach involves determining if an individual has a tumor characterized by undesirable myeloid cell proliferation and/or tumor infiltration and/or myeloid cell recruitment to the tumor, and if such determination is made, designating the individual as a candidate for the therapy. In one embodiment, the identification of the individual as such a candidate is followed by the therapeutic approach.
