A compound represented by the general formula (I) or a salt thereof:[Formula 1](see formula I)[T represents oxygen atom and the like； V represents CH2 and the like； R O1 toR O4represent hydrogen atom and the like； A represents a linear alkylene group orlinearalkenylene group having 2 to 8 carbon atoms and the like； D representscarboxyl groupand the like； X represents ethylene group, trimethylene group and the like； Erepresents -CH(OH)- group and the like； and W represent -U1-(R W1)(R W2)-U2-U3group(U1 represents a single bond, an alkylene group having 1 to 4 carbon atoms andthelike； R W1 and R W2 represent hydrogen atom and the like； U2 represents asingle bond,an alkylene group having 1 to 4 carbon atoms and the like； and U3 represent analkylgroup having 1 to 8 carbon atoms and the like), or a residue of a carbon ringorheterocyclic compound], which can be utilized as an active ingredient ofmedicamentseffective for prophylactic and/or therapeutic treatment of skeletal diseasessuch asosteoporosis and fracture, glaucoma, ulcerative colitis and the like.
