Dale Ando,Michael C. Holmes,Yann Jouvenot,Gary Ka Leong Lee
申请号：
US13068230
公开号：
US20120308528A1
申请日:
2011.05.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
