CRAIG A. ROSEN,STEVEN M. RUBEN,THEODORA SALCEDO,VIVIAN R. ALBERT,CLARIE LOUISE DOBSON,TRISTAN JOHN VAUGHAN
申请号：
PT02736661
公开号：
PT1572874E
申请日:
2002.05.07
申请国别(地区):
PT
年份:
2013
代理人:
摘要：
The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
