Disclosed are aqueous pharmaceutical compositions which provide sustained released delivery of corticosteroid compounds. The pharmaceutical composition comprises an insoluble corticosteroid； a soluble corticosteroid； and at least one viscosity enhancing agent. Also provided are methods for using the pharmaceutical compositions in an epidural injection, intra-articular injection, intra-lesional injection, or an intra-ocular injection.本發明揭示水性醫藥組合物，該等水性醫藥組合物提供皮質類固醇化合物之持續釋放傳遞。該醫藥組合物包含不可溶解皮質類固醇；可溶解皮質類固醇；及至少一種黏度增進劑。本發明亦提供在硬膜外(epidural)注射、關節內(intra-articular)注射、病灶內(intra-lesional)注射或眼內注射中使用該醫藥組合物之方法。
