Disclosed are aqueous pharmaceutical compositions which provide sustained released delivery of corticosteroid compounds. The pharmaceutical composition comprises a soluble corticosteroid and at least one viscosity enhancing agent. Also provided are methods for using the pharmaceutical compositions in an epidural injection, intra-articular injection, or an intra-lesional injection.本案揭示水性醫藥組成物,該等醫藥組成物可持續釋放遞送皮質類固醇化合物。該醫藥組成物包括可溶性皮質類固醇及至少一種增黏劑。本發明亦提供在硬膜外注射、關節內注射或病灶內注射方面使用該醫藥組成物的方法。