The described invention provides a topical bioadhesive film-forming pharmaceutical composition formulated for application directly to skin or to a substrate. The composition includes a therapeutic amount of an active agent； and one or more excipients selected from the group consisting of a non-cellulosic polymer or copolymer, a film forming agent, a plasticizer, a permeation enhancer, an antioxidant, a preservative, a solubilizer, a phase transfer catalyst, a viscosity modifier, a vitamin, a mineral nutrient, a solvent, a colorant and a fragrance. It further provides a delivery system comprising the composition and a means for administering the composition. It also describes uses of the delivery system in the manufacture of a medicament for treating a skin condition, disease or disorder, and a method for treating a skin condition, disease or disorder with the composition. The composition is characterized by: controlled release. The formed film is characterized by: locally sustained levels of a minimum effective concentration (MEC) of the active agent between applications； its adherence and conformance to a surface of the skin； its pliability, its resistance to breaking under tension (tensile strength)； maintained potency of the active agent； and removability of the film from the skin without a residue.La présente invention concerne une composition pharmaceutique filmogène bioadhésive pour administration par voie topique formulée pour une application directe sur la peau ou sur un substrat. La composition comporte une quantité thérapeutique d'un agent actif； et un ou des excipient(s) choisi(s) parmi le groupe constitué d'un polymère ou copolymère non-cellulosique, d'un plastifiant, d'un agent filmogène, d'un agent amplificateur de perméation, d'un antioxydant, d'un conservateur, d'un agent de solubilisation, d'un catalyseur de transfert de phase, d'un modificateur de viscosité, d'une vitamine, d'un nutriment minéral, d'un solvant, d'un colorant et d'un parfum. La prés
