Provided are drug delivery compositions and devices useful for the treatment and/or prevention of cancer and metastatic tumors. For example, a drug delivery composition and/or device is provided that comprises a biodegradable scaffold or biomaterial comprising one or more agents that inhibit one or more proinflammatory pathways, such as one or more immune responses mediated by a p38 mitogen-activated protein kinase (MAPK) pathway. In some embodiments, a drug delivery composition and/or device may further comprise one or more agents that activate the innate immune system (e.g., STING agonists) and/or the adaptive immune system (e.g., anti-PD- 1 antibodies). In some embodiments, a drug delivery composition and/or device may include a cytokine (e.g., IL- 15 superagonist). In some embodiments, a drug delivery composition and/or device can be administered to a tumor resection site (e.g., a void volume resulting from a tumor resection). Such intraoperative administration can prevent tumor regrowth and/or tumor metastasis. Also provided are methods of making drug delivery compositions and devices as well as kits containing materials to provide the same.L'invention concerne des compositions et dispositifs d'administration de médicament utilisables pour le traitement et/ou la prévention du cancer et de tumeurs métastatiques. L'invention concerne, par exemple, une composition et/ou un dispositif d'administration de médicament qui comprend/comprennent une matrice ou biomatériau biodégradables comprenant un ou plusieurs agent(s) qui inhibe(nt) une ou plusieurs voie(s) pro-inflammatoire(s), telles qu'une ou plusieurs réponse(s) immunitaire(s) médiée(s) par la voie de la MAPK (pour "mitogen-activated protein kinase") p38. Dans certains modes de réalisation, une composition et/ou un dispositif d'administration de médicament peut/peuvent en outre comprendre un ou plusieurs agent(s) qui active(nt) le système immunitaire inné (par exemple<；i />； des agonistes de STING) et/ou le s
