A method of deploying multiple filtering elements within selected vasculature includes the steps of delivering and deploying a first filtering element over a primary guidewire to a first vessel branching off a main vessel, locking the first filtering element onto the primary guidewire at a desired location within the first branching vessel, delivering a secondary guidewire to a second vessel branching off the main vessel, delivering a second filtering element over the secondary guidewire to the second branching vessel, deploying the second filtering element at a desired location within the second branching vessel, and locking the second filtering element onto the primary guidewire at the desired location associated with the second branching vessel.