RECEPTEUR DU FOLATE ET TRANSPORTEUR DU FOLATE SELECTIFS COUPLES AUX PROTONS, ET COMPOSES INHIBITEURS DE LA GARFTASE ET METHODES D'UTILISATION ASSOCIEES
WAYNE STATE UNIVERSITY;DUQUESNE UNIVERSITY OF THE HOLY SPIRIT
发明人:
GANGJEE, ALEEM,MATHERLY, LARRY H.
申请号：
CA2739250
公开号：
CA2739250C
申请日:
2009.09.30
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Fused cyclic pyrimidine compounds, including tautomers thereof, andpharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof,are disclosed. Thesecompounds are useful in methods for treating cancer, selectively targetingcancerous cells viathe proton coupled folate transporter, folate receptor alpha, and/or folatereceptor betapathways, inhibiting GARFTase in cancerous cells, and selectively targetingactivatedmacrophages in a patient having an autoimmune disease, such as rheumatoidarthritis.
