A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability. [wherein R 1a , R 1b , R 1c and R 1d each independently represent hydrogen, etc.； R 2 represents optionally substituted phenyl, etc.； R 3 represents optionally substituted C6-10 aryl, etc.； and Z 1 and Z 2 each independently represent hydrogen]
