IM, DAE SEONG,任大成,任大成,LEE, JAE MIN,李才敏,李才敏,LEE, JONG SOO,李锺守,李鍾守,BAE, SUNG MIN,裵城敏,裵城敏,KWON, SE CHANG,权世昌,權世昌
申请号：
TW100138828
公开号：
TWI494120B
申请日:
2011.10.26
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
Disclosed is a liquid formulation in which a long-acting INFα conjugate that has improved in vivo duration and stability can be stored stably for a long period of time. It comprises a stabilizer comprising a buffer, a sugar alcohol, a non-ionic surfactant and an isotonic agent. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting INFα conjugates.本發明揭示一種可長時間安定保存之改善了在體內持續性及安定性之長效INFα接合物之液體調配物。該液體調配物包括一種安定劑,該安定劑包括緩衝液、糖醇、非離子性界面活性劑及等張劑。該液體調配物不含人類血清白蛋白及其他可能對人體有害的因子,係無須擔心病毒性感染且保證具有優異的保存安定性之長效α-型干擾素接合物。由於本案的圖為實施例的結果數據,並非本案的代表圖。故本案無指定代表圖。
