conjugate, composition comprising conjugates, pharmaceutical composition, use of a conjugate or composition and process for the preparation of a conjugate or composition
"A conjugate, composition comprising conjugates, pharmaceutical composition, use of a conjugate or composition, process for the prophylactic and / or therapeutic treatment of disorders and process for preparing a conjugate or composition". erythropoietin glycoprotein conjugates are exposed, said conjugates comprising an erythropoietin glycoprotein that is endowed with at least one free amino group and having the in vivo biological activity of causing bone marrow cells to increase reticulocyte production and red blood cells and selected from the group consisting of human erythropoietin and its analogs having the major structure of human erythropoietin modified by the addition of 1 to 6 glycosylation sites or the reordering of at least one glycosylation site； said glycoprotein being covalently linked to form one to three lower poly (ethylene glycol) alkoxy groups, each of the poly (ethylene glycol) groups being covalently linked to glycoprotein via a binder of the formula -c (o) -xsy with the b (o) of the binder forming an amide agglutination with one of said amino groups, wherein x and y are as defined in the description and claims, the average molecular weight of each poly (ethylene glycol) moiety is from about 20 kilodaltons to about 40 kilodaltons, and the molecular weight of the conjugate ranges from about 51 kilodaltons to about 175 kilodaltons."<；um>；conjugado, composição que compreende conjugados, composição farmacêutica, utilização de um conjugado ou uma composição, processo para o tratamento profilático e/ou terapêutico de distúrbios e processo para a preparação de um conjugado ou composição<；mv>；". expõem-se conjugados de glicoproteína de eritropoietina, os ditos conjugados compreendendo uma glicoproteína de eritropoietina que é dotada de pelo menos um grupo amino livre e tendo a atividade biológica in vivo de fazer com que as células da medula óssea aumentem a produção de reticulócitos e de células vermelhas do sangue e selecionado a partir do grup
