The present invention relates to the combinations of lupeol acetate and curcumin at low dosage, and their use for the treatment or prevention of activated osteoclast precursor related diseases, including rheumatoid arthritis and osteoporosis.本發明係關於以羽扇豆醇醋酸及薑黃素之協同組合物,用於治療或預防蝕骨細胞前驅物活化相關疾病,包括類風濕關節炎及骨質疏鬆症。