Machine for the preparation of tablets comprising a support, a plate provided with stakes, an extractable plate, whose width guarantees that all the stakes are covered, another plate provided with a series of through holes, geometrically positioned as the stakes on the plate, characterized in that said machine comprises positioning means configured so that said plates can be stacked on said support so that the position of said stakes and said through holes arranged as said stake coincides, thus allowing to interpose removably said extractable plate between said staked plate and said plate provided with through holes.