CONTE, AURELIA,KUEHNE, HOLGER,LUEBBERS, THOMAS,MATTEI, PATRIZIO,MAUGEAIS, CYRILLE,MUELLER, WERNER,PFLIEGER, PHILIPPE
申请号：
ES07726239
公开号：
ES2387323T3
申请日:
2007.01.29
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula I ** Formula ** in queR1, R2, R4 and R5 are independently hydrogen, C1-C6alkyl, C1-C6alkoxy or halogen R3 is C1-C6 alkyl, halogeno-C1-C6 , C3-C6 cycloalkyl, Si (C1-C6alkyl) 3, -OR12, wherein R12 is C1-C6alkyl, halogeno-C1-C6 alkyl, C3-C6 cycloalkyl, phenyl, benzyl or S (O) 2-alkyl C1-C6, or pentafluorsulfuranilo or R2 and R3 together with the carbon atoms to which they are attached form a carbocyclic 5- or 6-membered oun heterocyclic 5- or 6-membered ring containing one or two heteroatoms selected from N, O and S R6 is hydrogen or C1-C6 alkyl R7 and R8 are independently hydrogen, C1-C6 alkyl, hydroxy or halogen R9 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, halogeno-C1-C6 alkyl, heterocyclyl , heteroaryl, phenyl, naphthyl, -OR13, wherein R13 is C1-C6 or phenyl, -NR14R15 alkyl wherein R14 and R15 are independently hydrogen, C1-C6 alkyl or phenyl, or -C (O) - OR16, wherein R16 is hydrogen or C1-C6 alkyl R10 and R11 are independently hydrogen, halogen, C1-C6 alkyl, COR wherein R is C1-C6alkyl, C1-C6o C3-C6cycloalkyl, S (O) 2-C1 C6, C3-C6 cycloalkyl or phenyl or together they are C1-C6 alkyl A is CR17 or N, wherein R17 is hydrogen, C1-C6 alkyl, C1-C6 or C2-C6 alkenyl B is CR18 or N, wherein R18 is hydrogen, halogen, C1-C6 alkyl, C1-C6 or C2-C6 alkyl D is CR19 or N, wherein R19 is hydrogen, halogen, C1-C6 alkyl, C1-C6 alkyl, C2-C6 or phenyl E is CR20 or N, wherein R20 is hydrogen, halogen, C1-C6 alkyl, C1-C6 alkyl or C2-C6 alkenyl oE is CR20 and -ABD- is -NO-, -NR21-N-, -Sn-, -S-CH- or -CH-S-, wherein R21 is hydrogen, C1-C6 alkoxy C1- C6 or C2-C6 alkenyl oE is N and -ABD- is -NO-, -Sn-, -S-CH-, -CH-CH- or -CH-S- oE is S and -CH-CH- -ABD- is n is the number 1, 2 or 3 and all pharmaceutically acceptable salts thereof.Un compuesto de la fórmula I **Fórmula**en la queR1, R2, R4 y R5 son con independencia hidrógeno, alquilo C1-C6, alcoxi C1-C6 o halógenoR3 es alquilo C1-C6, halogeno-alquilo C1-C6, cicloalquilo C3-C6, Si(alquilo C1-C6)3, -OR12, en el que R12
