Method for preparing 20 (S)-Protopanaxadiol having advantages of simple operation, low equipment requirement, time saving, high conversion efficiency, high product purity and suitable for industrial fabrications
The present invention provides a method for preparing 20 (S)-Protopanaxadiol, which utilizes high boiling point solvents to perform alkaline hydrolysis of an extract containing panaxadiol saponins under the conditions of inert gas protection, strong alkali, high temperature and atmospheric pressure, obtaining 20 (S)-Protopanaxadiol, which is then purified by column chromatography and recrystallization. The purity of the product is over 90%. This invention has the advantages of simple operation, low equipment requirement, time saving, high conversion efficiency, high product purity, and suitable for industrial fabrications.本發明提供一種20(S)-原人參二醇的製備方法,利用高沸點溶劑,在惰性氣體保護、強鹼、高溫、常壓條件下,將含有人參二醇型皂苷的提取物鹼解,獲得20(S)原人參二醇,經柱層析和重結晶純化後,產物純度達90%以上。本發明操作簡單、對設備要求低、時間短、轉化效率高、產物純度高,適於工業化生產。
