METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人:

Luk VANDENBERGHE,Guangping GAO,James M. WILSON

申请号：

US16818130

公开号：

US20200208176A1

申请日:

2020.03.13

申请国别(地区):

US

年份:

2020

代理人:

摘要：

A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.

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中国工程科技知识中心

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http://www.ckcest.cn/home/