The present invention is a gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, liver cancer, head and neck cancer, gallbladder cancer, and of diseases associated with cells expressing CLD18, including tumor-related diseases, including their metastasis treatment and / or prevention It provides useful antibodies as therapeutic agents for.stomach, CLD18, antibodies본 발명은 위암, 식도암, 췌장암, 폐암, 난소암, 결장암, 간암, 두경부암, 담낭암 및 이의 전이를 비롯한 종양 관련 질병을 포함하는 CLD18을 발현하는 세포와 관련된 질병의 치료 및/또는 예방을 위한 치료제로서 유용한 항체를 제공한다.