BERNARDO BRUNO DIAS BARACHO,IRAMI ARAÚJO FILHO,JOHERBSON DEIVID DOS SANTOS PEREIRA,JOSÉ HERIBERTO OLIVEIRA DO NASCIMENTO,LIVIA DOS ANJOS TAVARES,MAGNALDO INÁCIO TAVARES MEDEIROS,MARIA APARECIDA MEDEIR
申请号：
BR102019015537
公开号：
BR102019015537A2
申请日:
2019.07.29
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
nanoformulation developed based on copaíba oil for topical use in the healing process associated with laser in the present invention, copaíba oil (ocp) of the species copaifera reticulata ducke (ocpr), copaifera multijuga hayne (ocpm), and a commercial sample , were transmitted (preferential range 0.5% - 3.0%) in nanoemulsion snedds (self-nanoemulsifying drug delivery system), for topical use associated with laser, in the treatment of cutaneous tissue repair. the sneddsocpr, ocpm or ocpc (snedds-ocp) formulations were prepared without co-surfactant, aiming to reduce carrier ingredients that can avoid adverse reactions. snedds-ocp contains copaiba oil mixed with sunflower oil (1: 1) and a surfactant for pharmacological use (preferential range 7% - 25%), dispersed in a neutral aqueous medium. the snedds-ocp formulations were evaluated in in vivo treatments (rattus novergicus albinus) for wound healing. histopathological and immunohistochemical analyzes were performed after 7 and 14 days and showed a reduction in neutrophils and lymphocytes, as well as increased collagenesis, proliferation of fibroblasts and greater epithelial thickening. the pharmacological results showed an anti-inflammatory, healing and antiseptic response, via topical use, as well as an antinociceptive effect, via oral administration. comparatively, snedds-ocp formulations were more effective in the process associated with laser, in skin tissue repair.nanoformulação desenvolvida à base de óleo de copaíba para uso tópico em processo de cicatrização associado com laser no presente invento, o óleo de copaíba (ocp) das espécies copaifera reticulata ducke (ocpr), copaifera multijuga hayne (ocpm), e de uma amostra comercial, foram veiculadas (faixa preferencial 0,5% - 3,0%) em nanoemulsão snedds (self-nanoemulsifying drug delivery system), para uso tópico associado com laser, na terapêutica de reparo tecidual cutâneo. as formulações sneddsocpr, ocpm ou ocpc (snedds-ocp) foram preparadas sem co-surfactant
