SUN, Dawen,CHENG, Lina,ZHU, Zhiwei,ZENG, Xinan,WANG, Qijun,ZHANG, Zi
申请号：
EP15883840
公开号：
EP3267134A4
申请日:
2015.12.29
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
A method and device for freeze-drying medicine and liposome powder assisted by a variable-frequency alternating-current electric field, the method comprising the following steps: (1) preparing a medicine-liposome suspension sample (2) dehydrating the sample under a 1-10 kHz, 3-10 kV high-voltage alternating current (3) freezing and drying the sample treated in step (2) at -20 to -40ºC, under a 10-25 kHz, 0.2-1 kV high-voltage alternating current, and until the freezing process is completed (4) heating and drying the sample in a vacuum until sublimation and desorption are completed, and obtaining the medicine and liposome freeze-dried powder. The device comprises a preparation bin (1), a metering pump (2), a dehydrator (3) and a high/low-temperature treatment chamber (4) sequentially connected to each other. Electrode plates (32) are respectively provided above and below a sample tank (31) in the dehydrator (3). Electrode plates (42) are respectively provided above and below a sample tank (41) in the high/low-temperature treatment chamber (4). The electrode plates (32, 42) are connected to a high-voltage variable-frequency alternating-current power supply control cabinet (8). The high/low-temperature treatment chamber (4) is further connected to a vacuum pump (5), and configured to perform freeze-drying and heat-drying processes on the sample. By using the method, the device greatly shortens a freezing and drying time, and controls a size of nuclei and ice crystals, further ensuring a quality of the freeze-dried powder.
