KIM, Yoon-Keun,김윤근,PYUN, Bok Yang,편복양,KIM, Minhye,김민혜,CHOI, Jun-Pyo,최준표
申请号：
KRKR2016/002473
公开号：
WO2016/144139A3
申请日:
2016.03.11
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
The present invention relates to: a composition for preventing, ameliorating, or treating inflammatory diseases, the composition comprising, as active ingredients, lactic acid bacteria-derived extracellular vesicles isolated from culture fluid of lactic acid bacteria and a method for diagnosing atopic dermatitis. It was confirmed via in vitro and in vivo experiments that the lactic acid bacteria-derived extracellular vesicles according to the present invention are significantly more distributed in the urine and blood of a patient with inflammatory diseases than a normal person, and inflammatory response in epithelial cells and inflammatory cells caused by exposure to Staphylococcus or Pseudomonas-derived extracellular vesicles is efficiently inhibited by the lactic acid bacteria-derived extracellular vesicles. Thus, the composition comprising the lactic acid bacteria-derived extracellular vesicles as active ingredients is expected to be usefully used in development of drugs, cosmetics, or health functional food for preventing, ameliorating, or treating inflammatory diseases such as atopic dermatitis, chronic rhinitis, chronic sinusitis, asthma, chronic obstructive pulmonary disease, sepsis, etc. Also, the composition will be usefully used for diagnosis of atopic dermatitis by measuring the distribution of lactic acid bacteria-derived extracellular vesicles in a urine or blood sample.La présente invention concerne : une composition pour prévenir, améliorer ou traiter des maladies inflammatoires, la composition comprenant, comme principes actifs, des vésicules extracellulaires dérivées de bactéries dacide lactique isolées de fluide de culture de bactéries dacide lactique et un procédé pour diagnostiquer une dermatite atopique. Il a été confirmé, par lintermédiaire dexpériences in vitro et in vivo, que les vésicules extracellulaires dérivées de bactéries dacide lactique de la présente invention sont considérablement davantage réparties dans lurine et le sang dun patien
