ATTWELL SARAH C,MCLURE KEVIN G,HANSEN HENRIK C,WAGNER GREGORY S,KULIKOWSKI EWELINA B
申请号：
NZ59611710
公开号：
NZ596117A
申请日:
2010.04.21
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed herein is the use of quinazolin-4-one derivatives of formula (II) wherein the substituents are as defined within the specification, in the manufacture of a medicament for inhibiting the expression of IL-6 and/or VCAM-1 in a subject. Also disclosed are specific compounds including: 5-(2-dimethylamino-ethoxy)-2(4-hydroxy-3,5-dimethylphenyl)-7-methoxy-3Hquinazolin-4-one 2-(4-hydroxy-3,5-dimethyl-phenyl)-7-methoxy-5-(2-methoxy-ethoxy)-3Hquinazolin-4-one 7-(2-amino-ethoxy)-2-(4-hydroxy-3, 5-dimethyl-phenyl)-5-methoxy-3Hquinazolin-4-one 2-(4-hydroxy-3,5-dimethyl-phenyl)-5-methoxy-7-(2-methoxy-ethoxy)-3Hquinazolin-4-one 7-(2-benzyloxy-ethoxy)-2-(4-hydroxy-3,5-dimethyl-phenyl)-5-methoxy-3Hquinazolin-4-one 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one 7-(2-dimethylamino-ethoxy)-2-(4-hydroxy-3,5-dimethylphenyl)-3H-quinazolin-4-one 2-(4-hydroxy-3,5-dimethyl-phenyl)-6-(pyridin-4-ylamino)-3H-quinazolin-4-one 2-(4-hydroxy-3,5-dimethyl-phenyl)-6-(pyridin-2-ylamino)-3H-quinazolin-4-one 2-(4-hydroxy-3,5-dimethylphenyl)-6-((4-methylpiperazin-1-yl)methyl)quinazolin-4(3H)-one.
