VISCOMI, GIUSEPPE C.,CAMPANA, MANUELA,BRAGA, DARIO,CONFORTINI, DONATELLA,CANNATA, VINCENZO,RIGHI, PAOLO,ROSINI, GOFFREDO,VISCOMI, Giuseppe C.,CAMPANA, Manuela,BRAGA, Dario,CONFORTINI, Donatella,CANNATA, Vincenzo,RIGHI
申请号：
RSP29115
公开号：
RS20150291A1
申请日:
2004.11.04
申请国别(地区):
RS
年份:
2015
代理人:
摘要：
Crystalline polymorphic forms of rifaximin (INN), referred to as rifaximin &alpha； and rifaximin &bgr；, and a poorly crystalline form referred to as rifaximin &gamma；, useful in the production of medicaments containing rifaximin for the oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and causing the crystallization of the product by addition of water at a fixed temperature and for a fixed period of time, followed by drying under controlled conditions until reaching a precise water content in the end product, are the object of the invention.Objekt predmetnog pronalaska su kristalni polimorfni oblici rifaksimina (INN) označeni kao rifaksimin α i rifaksimina β, i slabo kristalni oblik nazvan rifaksimin γ, koji su korisni za proizvodnju medikamenata koji sadrže rifaksimin za oralnu i površinsku upotrebu i dobijeni su putem postupka kristalizacije obavljenog toplim rastvaranjem sirovog rifaksimina u etil alkoholu i izazivanjem kristalizacije produkta dodavanjem vode na određenoj temperaturi i tokom određenog vremenskog perioda, praćenog sušenjem u kontrolisanim uslovima, sve dok se ne dostigne precizni sadržaj vode u krajnjem produktu.
