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Bisplatinum complex with antitumor activity
专利权人:
チェル;インコーポレイテッド;-セデ;セコンダリア;テラペウティクス、;-セデ
发明人:
ベイアナレッジ、 アルベルト,グルグニ、 マリオ,マリオッティ、 ギウリオ,メンタ、 エルネスト,パルディ、 ジアンルカ,パヴェシ、 パオロ,ペッゾニ、 ガブリエラ,ニコリ、 パオロ,デ ムナリ、 セルジオ
申请号:
JP2008546261
公开号:
JP5436862B2
申请日:
2006.12.21
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
A compound of general formula (I): in which: R is selected from the group consisting of (C1-C25)alkyl, (C2-C25)alkenyl, aryl, (C7-C10)aralkyl; n and m are each independently an integer of two to eight; p is one or two; A is selected from the group consisting of -B-, -B-(CH2)r-B-, -B-(CH2)r-B-(CH2)z-B-, wherein r and z are an integer from 2 to 8, B is a -NR1- or -N(R2)2+1/pQ-p group, in which R1 is selected from hydrogen, (C1-C4)alkyl, (C1-C4)acyl, tert-butoxycarbonyl, and R2 is selected from hydrogen and (C1-C4)alkyl; Q-p is an anion selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R3COO- wherein R3 has the same meanings as R, independently from one another and R4-O-SO3- wherein R4 is (C2-C14)alkyl with the proviso that, when Q-p is selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R is not (C1-C4)alkyl.
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