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Bis-platinum complexes with antitumor activity
专利权人:
Inc. - Sede Secondaria;Cell Therapeutics
发明人:
Grugni, Mario,Menta, Ernesto,Pavesi, Paolo,De Munari, Sergio,Pezzoni, Gabriella,Pardi, Gianluca,Bernareggi, Alberto,Mariotti, Giulio,Nicoli, Paola
申请号:
AU2006328970
公开号:
AU2006328970B2
申请日:
2006.12.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
A compound of general formula (I): in which: R is selected from the group consistingof (C-C)alkyl, (C-C)alkenyl,aryl, (C-C)aralkyl; n and m are each independently aninteger of two to eight; p is one or two; A is selected from the group consistingof -B-, -B-(CH)r-B-, -B-(CH)-B-(CH)-B-,wherein r and z are an integer from 2 to 8, B is a -NR- or -N(R)l/pQ group, in which Rl is selected from hydrogen, (C-C)alkyl,(C-C)acyl, tert-butoxycarbonyl, and R isselected from hydrogen and (C-C)alkyl; Qis an anion selected from chloride, bromide, iodide, nitrate, sulphate, hydrogensulphate, perchlorate, RCOO wherein R hasthe same meanings as R, independently from one another and R-O-SOwherein R is (C-C)alkyl with the provisothat, when Q is selected from chloride, bromide, iodide, nitrate,sulphate, hydrogen sulphate, perchlorate, R is not (C-C)alkyl.
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