OLIGONUCLÉOTIDE ANTISENS DESTINÉ À ÉLIMINER DES SITES DE CLIVAGE PROTÉOLYTIQUES DE PROTÉINES

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专利权人:

Academisch Ziekenhuis Leiden h.o.d.n. LUMC

发明人:

申请号：

EP11741306.2

公开号：

EP2601294B1

申请日:

2011.08.04

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Described are means and methods for removing a proteolytic cleavage site from a protein, the method comprising providing a cell that expresses pre-mRNA encoding the protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that encodes the proteolytic cleavage site, and allowing translation of mRNA produced from the pre-mRNA.

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中国工程科技知识中心

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http://www.ckcest.cn/home/