SHEN, DONG-MING,GRAHAM, THOMAS H.,LIU, WENSHENG,TUDGE, CLARE,VERRAS, ANDREAS,JIANG, JINLONG
申请号：
CA3043203
公开号：
CA3043203A1
申请日:
2017.11.13
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to a compound represented by formula I': and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 ("DGAT2") and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
