Disclosed are methods and systems for non-invasive ultrasound neuromodulation of neural targets for the treatment of clinical conditions. These include neuromodulation of the occipital nerves to treat migraine and cluster headaches in their multiple variations as well other pain and tension conditions, the Sphenopalatine Ganglion and associated neural structures vidian nerve and/or sphenopalatine nerve to treat migraine and cluster headaches as well as other indications such as neurologic and psychiatric conditions, and the Reticular Activating System for a variety of clinical purposes such as reversibly putting a patient to sleep or waking them up (for example, for the purpose of anesthesia) or reversibly putting a patient into a coma (for example for the purpose of protecting or rehabilitating the brain of the patient after a stroke or head injury). Other clinical applications include neuromodulation of the Motor Cortex and other areas of the brain impacted by stroke for mitigating the effects of stroke and/or in stroke rehabilitation, pain-related targets to treat acute or chronic pain, tinnitus-related targets to treat that condition, and targets for the treatment of Post-Traumatic Stress Disorder. Use of ultrasound neuromodulation in sessions can enhance the effects.
