Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat movement disorders (e.g., tremor disorders such as Parkinsons Disease and essential tremor, Tourettes Syndrome, and epilepsy). Also included are the Tourettes vocalizations. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training Included is control of direction of the energy emission, intensity, frequency, pulse duration, firing pattern, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation.
