Provided herein are methods for decreasing Ataxin-2 mRNA expression. Such methods are useful to ameliorate symptoms of Ataxin-2 associated diseases. Such Ataxin-2 associated diseases include amyotrophic lateral sclerosis (ALS). Such symptoms include loss of motor function, reduced compound muscle action potential (CMAP) amplitude, denervation, and loss of motor neurons. Specifically, the methods comprising administering to an animal having ALS an oligomenc compound comprising a modified oligonucleotide, wherein the modified oligonucleotide has a nucleobase sequence that is complementary to an Ataxin-2 nucleic acid.
