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PROCESS TO PRODUCE FIBRILLAR PROTEINS AND METHOD OF TREATMENT USING FIBRILLAR PROTEINS
专利权人:
Shu-Mei Liang
发明人:
Shu-Mei Liang,Chun-Yung Huang,Chi-Ming Liang
申请号:
US13572652
公开号:
US20120316117A1
申请日:
2012.08.12
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A method for inhibiting survival of cancer cells in a subject is disclosed. The method comprises administering to a subject in need thereof a therapeutically effective amount of fibrillar albumin. The preparation of the fibrillar albumin comprises: (i) forming a solution comprising an isolated and/or purified globular albumin (ii) adding a detergent to the solution containing the isolated and/or purified globular albumin, wherein the detergent is one selected from the group consisting of sodium dodecyl sulfate (SDS) and n-tetradecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate (iii) applying the solution to a molecular sizing column with a pore size that permits separation of a protein with a molecular weight of at least about 70 kDa so as to promote column-induced formation of the fibrillar albumin from the isolated and/or purified globular albumin and (iv) eluting the fibrillar albumin from the column, wherein the eluted albumin has a fibrillar structure.
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