Tucker Curran Roberts,Peter Andrew Smith,David Campbell,Sergio G. Duron,Robert I. Higuchi
申请号：
US15358100
公开号：
US10501493B2
申请日:
2016.11.21
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided herein are analogs of the natural product arylomycin for the treatment of microbial infections. In some embodiments, the compounds described herein have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broader spectrum of antibiotic bioactivity compared to the natural product. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
