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PYRROLES CONDENSÉS ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE CRAC
专利权人:
GRÜNENTHAL GMBH
发明人:
VOSS, Felix,RITTER, Stefanie,NORDHOFF, Sonja,WACHTEN, Sebastian,OBERBÖRSCH, Stefan,KLESS, Achim
申请号:
EPEP2014/002218
公开号:
WO2015/022073A1
申请日:
2014.08.13
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
The invention relates to substituted bicyclic pyrroloheterocyclyl compounds of general formula (I), wherein A1 and A2 represent direct bond or C(=O), with the proviso that 0 or 1 of A1 and A2 represents C(=O); m and n independently denote 0, 1, 2 or 3, with the proviso that the sum [n + m] is 1, 2, 3 or 4; R1 denotes H, F, CI, Br, I, CN, CF3, CF2H, CFH2, CO2H, CO2R13, R13, OH. O-R13, NH2, N(H)R13, N(R13)2, R2 represents 0 to 4 substituents, each independently selected from F, CI, Br, CN. CF3, CF2H, CFH2, R13, OH, O-R13, NH2, N(H)R13 and N(R13)2; Ar1 represents phenyl or 5- or 6-membered heteroaryl, in each case unsubstituted or substituted with one, two, three or four substituents, independently selected from F, CI, Br, CN, CF3. CF2H, CFH2, R13 and O- R13; or C3-6-cycloalkyl or 3 to 7 membered heterocycloalkyl, in each case unsubstituted or mono- or polysubstituted; Ar2 represents phenyl or 5- or 6-membered heteroaryl, wherein said phenyl or said heteroaryl may be unsubstituted or mono- or polysubstituted and may be condensed with a 4-, 5-, 6-or 7- membered ring, being carbocyclic or heterocyclic, wherein said condensed ring may be saturated, partially unsaturated or aromatic and may be unsubstituted or mono- or polysubstituted; useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to these compounds for the use in the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.L'invention porte sur des composés bicycliques substitués comportant un groupe pyrrolo et un groupe hétérocyclyle représentés par la formule générale (I), dans laquelle A1 et A2 représentent une liaison directe ou C(=O), à condition que 0 ou 1 de A1 et A2 représente C(=O); m et n désignent chacun indépendamment 0, 1, 2 ou 3, à condition que la somme [n + m] vaille 1, 2, 3 ou 4; R1 désigne H, F, CI, Br, I, CN, CF3, CF2H, CFH2, CO2H, CO2R13, R13, OH, O-R13, NH2, N(H)R13 ou N(R13)2; R2 représente
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