JULIA JANE, MONTSERRAT,CARRERA CARRERA, FRANCESC,PRAT QUINONES, MARIA,PUIG DURAN, CARLOS,PAJUELO LORENZO, FRANCESCA,PEREZ ANDRES, JUAN ANTONIO
申请号：
PE2015001752
公开号：
PE20151602A1
申请日:
2014.02.27
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
1. The invention refers to a solution produced by sulphuric acid, hydrazine or sulfur derivatives or pharmaceutically acceptable solution, and (2) an addictive salt produced by 2-amino-1-hydroxidil-8-hydroximinolin-2 (1H) - formula ona (I) derivatives and pharmaceutically acceptable crystallization and pharmaceutically acceptable addictive salt；Wherein: R1 represents a hydrogen atom or C1-C4 tar group； R2 and R3 independently represent a hydrogen atom, a halogenated atom, etc.； a represents an optional C1-C4 tar group, which is replaced by one or more C1-C2 tar groups； l represents a direct link, a - NH (CO) group,Other popular salts include: acetylhydrazine (di-2-tienil) acetic acid trans-4 - ((3 - (2-Chloro-4 - ((2R) - 2-hydroxy-2 - (8-hydroxy-2-oxo-1, 2-di-di-di-di-di-di-tri-ethylamine) methyl) - 5-methoxyethylamine-3-oxopolpil (methyl) amine) - cyclohexane； 2-di (tiofen-2-il) acetic acid trans-4 - (2 - (2) - chloro-4 - ((R) - 2-hydroxi-2 - (8-hydroxi-2-oxo-1, 2-dihydroquinlin-5-il) ethylamine) - methyl) - 5-methylcarbamiloxi) ethyl - (methyl) amine) - cyclohexane, andSalt tartrade 2-hydroxi-2, 2-di (tiofen-2-il) acetic acid trans-4 - (2 - (2 - (2-Chloro-4 - ((R) - 2-hydroxi-2 - (8-hydroxi-2-oxo-1, 2-dihydroquinolin-5-il) ethane) - methyl) - 5-methylcarbamoilloxil (ethyl) - 5 - (methyl) amineLa presente invencion se refiere a sales de adicion cristalinas y farmaceuticamente aceptables de (i) derivados de un acido sulfonico o hidroxicarboxilico o un derivado sulfimida, o un solvato farmaceuticamente aceptable del mismo y (ii) un derivado de 2-amino-1-hidroxietil-8-hidroxiquinolin-2(1H)-ona de formula (I)； donde: R1 representa un atomo de hidrogeno o un grupo alquilo C1-C4； R2 y R3 independientemente representan un atomo de hidrogeno, un atomo de halogeno, etc； A representa un grupo alquileno C1-C4 opcionalmente sustituido con uno o mas grupos alquilo C1-C2； L representa un enlace directo, un grupo -NH(CO)-, etc. Las sales preferidas son: etanodisulfonato de hidrox
