The present invention relates to bispecific constructs that specifically bind to cytotoxic T cells and simultaneously target cells bearing IL-5R, as well as nucleic acids, vectors, host cells, pharmaceutical compositions, and methods for their production and use. Use of the bispecific construct in the treatment of inflammation and / or autoimmune diseases and cancer.本発明は、細胞障害性Ｔ細胞と、同時にＩＬ－５Ｒ担持標的細胞に特異的に結合する二重特異性構築物、並びに核酸、ベクター、宿主細胞、医薬組成物、及びそれらの製造方法及び使用に関し、炎症及び／又は自己免疫疾患及び癌の治療における当該二重特異性構築物の使用を含む。
