SONG, DAE HAE,宋大海,LIM, CHANG KI,林昌基,SONG, TAE HUN,宋台宪,宋台憲,KIM, YOUNG HOON,金永勳,KWON, SE CHANG,权世昌,權世昌,LEE, GWAN SUN,李宽淳,李寬淳,JUNG, SUNG YOUB,郑圣烨,鄭聖燁,CHOI, IN YOUNG,崔仁荣,崔仁榮
申请号：
TW097107631
公开号：
TWI413528B
申请日:
2008.03.05
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and an immunoglobulin Fc region, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.本發明係關於促胰島素肽共軛物，具有經改善之活體內效力和穩定性持續時間，包括促胰島素肽、非-肽聚合物和免疫球蛋白Fc區，其以共價方式彼此連接，及相同物的用途。本發明之促胰島素肽共軛物具有維持在相對較高的活體內活性，且具有明顯增加的血液半衰期，並因此可能想要在發展各種肽藥物之長效調配物時使用它。
