This invention provides an apparatus for generating negative pressure, including a vacuum pump, a sound-isolation module and a noise-reducing pipeline module. The vacuum pump has an inlet end and an outlet end. The sound-isolation module has an accommodation space for placing the vacuum pump. The sound-isolation module is used for insolating noise and vibration generated by the vacuum pump itself from the surrounding when it is operated. The noise-reducing pipeline module includes a flexible inlet pipeline with an opening communicated with the inlet end of the vacuum pump, and a flexible outlet pipeline with an opening communicated with the outlet end of the vacuum pump. The noise-reducing pipeline module is used for eliminating the noise of the inlet and outlet ends of the vacuum pump. The present apparatus can provide a vacuum source to an oral device to generate a negative pressure environment inside oral cavity of a user to maintain the user’s upper airway patency.本發明提供一種負壓產生裝置,包括一真空幫浦、一隔音模組及一消音管路模組。該真空幫浦具有一進氣端及一排氣端,該隔音模組具有一容置空間供放置該真空幫浦,該隔音模組用以隔離該真空幫浦運轉產生的噪音及振動。該消音管路模組包含一可撓性進氣管,其一開口端連通於該真空幫浦之該進氣端,及一可撓性排氣管,其一開口端連通於該真空幫浦之該排氣端。該消音管路模組用以減低該真空幫浦運轉時其進氣端及/或其排氣端的噪音。該負壓產生裝置可提供一真空源予一口部介面裝置,以利於在使用者口腔內產生負壓環境以維持該使用者上呼吸道暢通。10‧‧‧真空幫浦模組101‧‧‧可撓性進氣管102‧‧‧可撓性排氣管1030‧‧‧第一蓋體1034‧‧‧第二蓋體