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DERIVES DE DIAZACARBAZOLE A TITRE DE LIGANDS TAU-PET
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
GOBBI, LUCA,KNUST, HENNER,KOERNER, MATTHIAS,MURI, DIETER
申请号:
CA2917191
公开号:
CA2917191A1
申请日:
2014.10.06
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
The present invention relates to a compound of general formula (I) wherein R is hydrogen or tritium; F is fluoro or 18fluoro; or to a pharmaceutically acceptable acid addition salt. Compounds of formula I include 2-(6-fluoro-pyridin-3-yl)-9H-dipyrido[2,3-b;3',4'-d]pyrrole, 3H-2-(6-fluoro-pyridin-3-yl)-9H-dipyrido[2,3-b;3',4'-d]pyrrole and [18F]-2-(6-fluoro-pyridin-3-yl)-9H-dipyrido[2,3-b;3',4'-d]pyrrole. The compounds may be used for binding and imaging tau aggregates and related beta-sheet aggregates including besides others beta-amyloid aggregates or alpha-synuclein aggregates.
来源网站:
中国工程科技知识中心
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