PROBLEM TO BE SOLVED: To provide a therapeutic agent effective in ischemia-reperfusion injury of a heart.SOLUTION: The invention provides a method for treating ischemia-reperfusion injury of a heart using a therapeutic agent selected from a protein, polypeptide, peptide, peptidomimetic, nucleic acid, organic low molecular weight compound, antibody or a fragment or derivative thereof, soluble receptor (soluble CTLA4 molecule, preferably CTLA4Ig fusion protein), and aptamer, which can interact to at least either one of CD80 or CD86 polypeptide, the interaction interfering in the binding of at least either one of CD80 or CD86 polypeptide with CD28 polypeptide.COPYRIGHT: (C)2015,JPO&INPIT【課題】心臓温虚血再灌流障害に有効な治療剤の提供。【解決手段】CD80又はCD86ポリペプチドの少なくとも一方と相互作用でき、前記相互作用が、CD80又はCD86ポリペプチドの少なくとも一方と、CD28ポリペプチドとの結合に干渉する、タンパク質、ポリペプチド、ペプチド、ペプチド模倣物、核酸、有機低分子化合物、抗体又はその断片若しくは誘導体、可溶性受容体(可溶性CTLA4分子、好ましくはCTLA4Ig融合タンパク質)、及びアプタマーから選択される治療剤を用いて、心臓温虚血再灌流障害を処置する方法。【選択図】図1
