SLEEMAN W MARK,GUSAROVA VIKTORIA,KIM JEE H,CHEN GANG
申请号：
IN6490/CHENP/2012
公开号：
IN2012CN06490A
申请日:
2012.07.23
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
A fully human antibody or antigen binding fragment of a human antibody that specifically binds and inhibits human angiopoietin like protein 4 (hANGPTL4) is provided. The human anti hANGPTL4 antibodies are useful in treating diseases or disorders associated with ANGPTL4 such as hyperlipidemia hyperlipoproteinemia and dyslipidemia including hypertriglyceridemia hypercholesterolemia chylomicronemia and so forth. Furthermore the anti hANGPTL4 antibodies can be administered to a subject in need thereof to prevent or treat diseases or disorders for which abnormal lipid metabolism is a risk factor. Such diseases or disorders include cardiovascular diseases such as atherosclerosis and coronary artery diseases acute pancreatitis nonalcoholic steatohepatitis (NASH) diabetes obesity.
