Mark W. Sleeman;Jee H. Kim;Viktoria Gusarova;Gang Chen
发明人:
Mark W. Sleeman,Viktoria Gusarova,Jee H. Kim,Gang Chen
申请号：
US12977361
公开号：
US08354103B2
申请日:
2010.12.23
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human angiopoietin-like protein 4 (hANGPTL4) is provided. The human anti-hANGPTL4 antibodies are useful in treating diseases or disorders associated with ANGPTL4, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth. Furthermore, the anti-hANGPTL4 antibodies can be administered to a subject in need thereof to prevent or treat diseases or disorders, for which abnormal lipid metabolism is a risk factor. Such diseases or disorders include cardiovascular diseases, such as atherosclerosis and coronary artery diseases； acute pancreatitis； nonalcoholic steatohepatitis (NASH)； diabetes； obesity； and the like.
