A pharmaceutical bolus preloaded injector device (1), applied to a hypodermic syringe (2) and a plunger (17, 22) of the prior art and for direct loading of a pharmaceutical bolus or a medicament. The pharmaceutical bolus preloaded injector device (1) comprises: a sterile seal plug (11) and a movable needle shaft (12, 18). The sterile seal plug (11) is pre-provided inside a syringe end (21) at a front end of the hypodermic syringe (2). The sterile seal plug (11) is located near an injection opening of the syringe end (21), and a recessed guide channel (110) is provided at the sterile seal plug. A sleeve (120) is provided at a front end of the movable needle shaft (12, 18). The sleeve (120) engages with an outer side of the syringe end (21). A longitudinal bevel (121) is provided at the front end of the movable needle shaft (12, 18), so that the movable needle shaft (12,18) can enter the guide channel (110) and penetrate the sterile seal plug (11) to access a storage space of the hypodermic syringe (2). The thickness of the sterile seal plug (11) is greater than the bevel length of the movable needle shaft (12, 18). Pharmaceutical liquid (31) can be directly provided in the storage space of the hypodermic syringe (2). Once the movable needle shaft (12,18) enters the storage space of the hypodermic syringe (2), the injection is ready to be administered directly to the patient, obviating the need for pharmaceutical packaging ampoules, vials or bottles, reducing the risk of medication error, improving medication dosage control and increasing convenience in off-site usage.La présente invention concerne un dispositif d'injecteur préchargé de bolus pharmaceutique (1), appliqué à une seringue hypodermique (2) et à un piston (17, 22) de l'état de la technique et pour le chargement direct d'un bolus pharmaceutique ou d'un médicament. Le dispositif d'injecteur préchargé de bolus pharmaceutique (1) comprend : un bouchon d'étanchéité stérile (11) et une tige d'aiguille mobile (12
