Anti-CTLA4-anti-PD-1 bifunctional antibody, pharmaceutical composition thereof and use thereof. Specifically, the anti-CTLA4-anti-PD-1 bifunctional antibody includes a first protein functional region that targets PD-1 and a second protein functional region that targets CTLA4. The bifunctional antibody can specifically bind well to CTLA4 and PD-1, can specifically eliminate immune suppression of CTLA4 and PD-1 against the living body, can activate T lymphocytes, and has good application There is a future. [Selection] Figure 52抗ＣＴＬＡ４－抗ＰＤ－１二機能性抗体、その医薬組成物およびその使用。具体的に、前記の抗ＣＴＬＡ４－抗ＰＤ－１二機能性抗体は、ＰＤ－１を標的とする第１タンパク質機能領域と、ＣＴＬＡ４を標的とする第２タンパク質機能領域を含む。当該二機能性抗体は、ＣＴＬＡ４およびＰＤ－１と特異的にうまく結合でき、特異的にＣＴＬＡ４およびＰＤ－１の生体に対する免疫抑制を取り除け、Ｔリンパ球を活性化させることができ、良好な応用の将来性がある。【選択図】図５２
