An endobronchial ultrasound (EBUS) bronchoscope is configured as a single-use(e.g.,disposable) device. The bronchoscope includes an insertion tube having aproximal sectionadjacent the handle and a distal tip. An ultrasound transducer assembly islocated at the distaltip. The ultrasound transducer assembly includes an ultrasound transducerarray, transmit-and-receivecircuitry for the ultrasound transducer array, and a flexible interconnectionbetween the ultrasound transducer array and the transmit-and-receivecircuitry. The insertiontube further includes an imaging lumen including one or more power cables andone or morecommunication wires that extend from the ultrasound transducer assemblythrough theproximal section and a working channel that is separate from the imaginglumen.