FERREIRA GON‡ALVES NUNO PAULO,CERCA MARTINS DOS SANTOS TANIA PATRICIA,PEREIRA NASCIMENTO COSTA GON§ALO,PEREIRA MONTEIRO CARLOS JORGE,SCHABERLE FABIO ANTONIO,CORREIA ALFAR SONIA,REIS DE ABREU ARTUR CAR
申请号：
IN201717033308
公开号：
IN201717033308A
申请日:
2017.09.20
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
This invention relates to atroipsomers of reduced tetraphenylporphyrin derivatives with halogen atoms (F CI Br) in the positions of the phenyl groups particularly halogenated tetraphenylchlorins and halogenated tetraphenylbacteriochlorins which can be used in photodynamic therapy. According to the formulae of the invention the o phenyl substituents X X X X X X X and Xmay be identical or different and represent halogen atoms or hydrogen atoms provided that at least all of X X X and X are halogens and the phenyl substituents R R R and R are independently chosen from OH OR or SOR where R are each independently chosen from CI OH aminoacid OR NHR or NR where R are alkyl of 1 to 12 carbon atoms or R represents cycloalkyl with 2 to 12 carbon atoms. The atropisomers of this invention have the majority of the substituents R R R and Ron the same side of the plane defined by the macrocycle. The invention also relates to an anticancer and/or antimicrobial and/or antiviral pharmaceutical composition where atropisomers a4 and a3 are the main active ingredients such that the mixture of atropisomers a4 and a3 constitutes more than 70% of the atropisomers present in the active ingredient and/or the atropisomer a4 constitutes more than 20% of the atropisomers present in the pharmaceutical composition.
