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Daily periodic target-zone modulation in the model predictive control problem for artificial pancreas for type I diabetes applications
专利权人:
The Regents of the University of California
发明人:
Francis J. Doyle, III,Eyal Dassau,Ravi L. Gondhalekar
申请号:
US14154241
公开号:
US20140200559A1
申请日:
2014.01.14
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A controller for an artificial pancreas for automated insulin delivery to patients with type 1 diabetes mellitus (T1DM) that enforces safe insulin delivery throughout both day and night, wherein the controller employs zone model predictive control, whereby real-time optimization, based on a model of a human's insulin response, is utilized to regulate blood glucose levels to a safe zone, and time-dependent zones that smoothly modulate the controller correction based on the time of day, wherein the controller strategically strives to maintain an 80-140 mg/dL glucose zone during the day, a 110-220 mg/dL zone at night, and a smooth transition of 2 hour duration in between.
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