Compositions comprising select natural products have been found to be useful as supplements to known medicaments for treating elevated blood glucose, HbAlc, blood pressure and cholesterol levels in persons suffering from metabolic syndrome, insulin resistance, and type 2 diabetes. The natural products of interest include polymethoxyflavones, flavonoids, liminoids, and tocotrienols, while the known medicaments include metformin. In preferred embodiments, the natural products are polymethoxyflavones found in citrus plants, such as nobiletin, tangeretin, and synephrin. Use of the natural product of interest will preferably result in HbAlc ≤ 7%, LDL-C ≤ 100 mg/dL, total cholesterol ≤ 200 mg/dL； and systolic blood pressure ≤ 130 mm Hg.
