Viola Groehn;Tobias Ludwig Ross;Simon Mensah Ametamey;Rudolf Moser
发明人:
Simon Mensah Ametamey,Rudolf Moser,Tobias Ludwig Ross,Viola Groehn
申请号：
US12595301
公开号：
US09315506B2
申请日:
2008.04.11
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.
