18F-labeled folic acid

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专利权人:

メルク エ カンパニー

发明人:

アメータメイ・ジーモン・メンザー,モーザー・ルードルフ,ロス・トビーアス・ルートヴィヒ,グレーン・ヴィーオラ

申请号：

JP2010502520

公开号：

JP5693950B2

申请日:

2008.04.11

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.

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